HORDB

ID: hor000717
Uniprot ID: Q9VCW0??52-60)
Protein name: Cardioactive peptide
Gene name: CCAP
Organism: Drosophila melanogaster (Fruit fly)
Family: NA
Source: animal
Expression: Central nervous system; most neurons exhibit coexpression with Burs.
Disease: NA
Comments: NA
Taxonomy: melanogaster subgroup, melanogaster group, Sophophora (subgenus), Drosophila (genus), Drosophilini (tribe), Drosophilinae (subfamily), Drosophilidae (family), Ephydroidea (superfamily), Acalyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0071855 neuropeptide receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0010460 positive regulation of heart rate
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: PFCNAFTGC
Length: 9(52-60)
Propeptide: MRTSMRISLRLLALLACAICSQASLERENNEGTNMANHKLSGVIQWKYEKRPFCNAFTGCGRKRTYPSYPPFSLFKRNEVEEKPYNNEYLSEGLSDLIDINAEPAVENVQKQIMSQAKIFEAIKEASKEIFRQKNKQKMLQNEKEMQQLEERESK
Signal peptide: MRTSMRISLRLLALLACAICSQA
Modification: T9 Cysteine amide
Glycosylation: NA
Mutagenesis: NA

Function: Cardioregulatory neurohormone that increases heart beat rate during adult wing inflation; has no effect on beat amplitude. The effect of CCAP is both ino- and chronotropic
Mechanism: NA
Cross BBB: NO
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000717_AF2.pdb

hor000717_ESM.pdb

Mass:	110198	Formula:	C42H58N10O12S2
Absent amino acids:	DEHIKLMQRSVWY	Common amino acids:	CF
pI:	5.84	Basic residues:	0
Polar residues:	5	Hydrophobic residues:	3
Hydrophobicity:	68.89	Boman Index:	206
Half-Life:	>20 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	?	Aliphatic Index	11.11
Instability Index:	2085.56	Extinction Coefficient cystines:	125
Absorbance 280nm:	15.63